This is the report from a meeting for regional consultations on key populations and HIV/AIDS that was held at the King Fahd Palace Hotel in Dakar, Senegal, on April 10, 2015.  The purpose of the meeting was to revamp efforts geared towards containing the HIV epidemic based on new scientific evidence; share the outcomes of various studies on the new trends of HIV spread among key populations; and agree on actions to reduce barriers that prevent key populations from gaining access to public health services.